BDBM482870 (S)-1-(2-(8-amino-1-(4-(benzyloxy)phenyl)imidazo[1,5-a]pyrazin-3-yl)pyrrolidin-1-yl)but-2-yn -1-one::US10919899, Compound 1

SMILES CC#CC(=O)N1CCC[C@H]1c1nc(-c2ccc(OCc3ccccc3)cc2)c2c(N)nccn12

InChI Key InChIKey=VDNUXYFPRAIBDE-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 482870   

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dongguan Zhenxing-Beite Medicine Technology

US Patent
LigandPNGBDBM482870(US10919899, Compound 1 | (S)-1-(2-(8-amino-1-(4-(b...)
Affinity DataIC50: 1.00E+4nMAssay Description:In the case of Km ATP, EGFR T790M/L858R protein kinase activity was tested by Caliper mobility shift assay (referring to J Biomol Screen 14:31, 2009)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2021
Entry Details
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TargetTyrosine-protein kinase ITK/TSK(Human)
Dongguan Zhenxing-Beite Medicine Technology

US Patent
LigandPNGBDBM482870(US10919899, Compound 1 | (S)-1-(2-(8-amino-1-(4-(b...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activities of the compound to Tec, Txk, and ITK of human were performed by Eurofins Pharma Discovery Services UK Limited (UK) of the U...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2021
Entry Details
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TargetTyrosine-protein kinase Tec(Human)
Dongguan Zhenxing-Beite Medicine Technology

US Patent
LigandPNGBDBM482870(US10919899, Compound 1 | (S)-1-(2-(8-amino-1-(4-(b...)
Affinity DataIC50: 218nMAssay Description:The inhibitory activities of the compound to Tec, Txk, and ITK of human were performed by Eurofins Pharma Discovery Services UK Limited (UK) of the U...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase TXK(Human)
Dongguan Zhenxing-Beite Medicine Technology

US Patent
LigandPNGBDBM482870(US10919899, Compound 1 | (S)-1-(2-(8-amino-1-(4-(b...)
Affinity DataIC50: 4.54E+3nMAssay Description:The inhibitory activities of the compound to Tec, Txk, and ITK of human were performed by Eurofins Pharma Discovery Services UK Limited (UK) of the U...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Dongguan Zhenxing-Beite Medicine Technology

US Patent
LigandPNGBDBM482870(US10919899, Compound 1 | (S)-1-(2-(8-amino-1-(4-(b...)
Affinity DataIC50: 100nMAssay Description:Activity of BTK protein kinase was tested by Caliper mobility shift assay (referring to J Biomol Screen 14:31, 2009). The compound of the present dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2021
Entry Details
Go to US Patent