BDBM4828 1-[2-amino-6-(2-bromo-6-chlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea::PD089828 analog 9

SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1c(Cl)cccc1Br

InChI Key InChIKey=CYJBQAMTIYIBGY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 4828   

TargetPlatelet-derived growth factor receptor beta(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM4828(1-[2-amino-6-(2-bromo-6-chlorophenyl)pyrido[2,3-d]...)
Affinity DataIC50: 620nMpH: 7.4 T: 2°CAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2005
Entry Details Article

TargetFibroblast growth factor receptor 1(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM4828(1-[2-amino-6-(2-bromo-6-chlorophenyl)pyrido[2,3-d]...)
Affinity DataIC50: 180nMAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2005
Entry Details Article

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM4828(1-[2-amino-6-(2-bromo-6-chlorophenyl)pyrido[2,3-d]...)
Affinity DataIC50: 210nMAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2005
Entry Details Article

TargetPlatelet-derived growth factor receptor alpha/beta(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM4828(1-[2-amino-6-(2-bromo-6-chlorophenyl)pyrido[2,3-d]...)
Affinity DataIC50: 620nMAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2005
Entry Details Article