BDBM48235 MLS000541553::N,N-dimethyl-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine::N,N-dimethyl-6-phenyl-3-pyridin-2-yl-1,2,4-triazin-5-amine::SMR000126411::cid_6404645::dimethyl-[6-phenyl-3-(2-pyridyl)-1,2,4-triazin-5-yl]amine

SMILES CN(C)c1nc(nnc1-c1ccccc1)-c1ccccn1

InChI Key InChIKey=HAFZKOVMNKGNKS-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 48235   

TargetHypoxia-inducible factor 1-alpha(Human)
The Broad Institute Probe Development Center

Curated by ChEMBL
LigandPNGBDBM48235(N,N-dimethyl-6-phenyl-3-(2-pyridinyl)-1,2,4-triazi...)
Affinity DataEC50:  9.82E+3nMAssay Description:Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHypoxia-inducible factor 1-alpha(Human)
The Broad Institute Probe Development Center

Curated by ChEMBL
LigandPNGBDBM48235(N,N-dimethyl-6-phenyl-3-(2-pyridinyl)-1,2,4-triazi...)
Affinity DataEC50:  9.06E+3nMAssay Description:Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHypoxia-inducible factor 1-alpha(Human)
The Broad Institute Probe Development Center

Curated by ChEMBL
LigandPNGBDBM48235(N,N-dimethyl-6-phenyl-3-(2-pyridinyl)-1,2,4-triazi...)
Affinity DataEC50:  7.46E+3nMAssay Description:Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14 [1-36](Human)
Sanford-Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM48235(N,N-dimethyl-6-phenyl-3-(2-pyridinyl)-1,2,4-triazi...)
Affinity DataEC50:  5.00E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2011
Entry Details
PCBioAssay