BDBM482274 9-(1-isopropylpiperidin-4-yl)-1- methyl-1,5,9,10-tetrahydro-1,2,4, 5,8,9-hexaazabenzo[cd]cyclopenta[h]azulene::US10918645, Example 83

SMILES CC(C)N1CCC(CC1)N1Cc2c(cnn2C)-c2n[nH]c3ccnc1c23

InChI Key InChIKey=YSNOCQFGMJLSDO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 482274   

LigandPNGBDBM482274(US10918645, Example 83 | 9-(1-isopropylpiperidin-4...)
Affinity DataIC50: 23nMAssay Description:TTBK1 (5-20 mU diluted in 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% β-mercaptoethanol, 1 mg/ml BSA, 10 mM DTT) is assayed against RRKDLHDDEEDEAMSITA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2021
Entry Details
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TargetTyrosine-protein kinase JAK2(Human)
Lifearc

US Patent
LigandPNGBDBM482274(US10918645, Example 83 | 9-(1-isopropylpiperidin-4...)
Affinity DataIC50: 4.50E+3nMAssay Description:JAK2 (5-20 mU diluted in 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.05% 0-mercaptoethanol, 1 mg/ml BSA) is assayed against PDKtide (KTFCGTPEYLAPEVRREPRILSEEEQ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2021
Entry Details
Go to US Patent