BDBM482264 8-fluoro-4-(tetrahydro-2H-pyran-4-yl)- 5,11-dihydro-4H-3,4,10,11- tetraazadibenzo[cd,h]azulene::US10918645, Example 61

SMILES Fc1ccc2CN(C3CCOCC3)c3nccc4[nH]nc(-c2c1)c34

InChI Key InChIKey=DSGOWECLCGJGIL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 482264   

LigandPNGBDBM482264(US10918645, Example 61 | 8-fluoro-4-(tetrahydro-2H...)
Affinity DataIC50: 57nMAssay Description:TTBK1 (5-20 mU diluted in 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% β-mercaptoethanol, 1 mg/ml BSA, 10 mM DTT) is assayed against RRKDLHDDEEDEAMSITA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2021
Entry Details
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TargetTyrosine-protein kinase JAK2(Human)
Lifearc

US Patent
LigandPNGBDBM482264(US10918645, Example 61 | 8-fluoro-4-(tetrahydro-2H...)
Affinity DataIC50: 900nMAssay Description:JAK2 (5-20 mU diluted in 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.05% 0-mercaptoethanol, 1 mg/ml BSA) is assayed against PDKtide (KTFCGTPEYLAPEVRREPRILSEEEQ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2021
Entry Details
Go to US Patent