BDBM482249 6-(tetrahydro-2H-pyran- 4-yl)-6,7,8,9- tetrahydro-2H-1,2,5,6- tetraazabenzo[cd]azulene::US10918645, Example 29

SMILES C1CC(CCO1)N1CCCc2n[nH]c3ccnc1c23

InChI Key InChIKey=YZOPGIAOMUMVSR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 482249   

LigandPNGBDBM482249(US10918645, Example 29 | 6-(tetrahydro-2H-pyran- 4...)
Affinity DataIC50: 150nMAssay Description:TTBK1 (5-20 mU diluted in 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% β-mercaptoethanol, 1 mg/ml BSA, 10 mM DTT) is assayed against RRKDLHDDEEDEAMSITA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2021
Entry Details
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TargetTyrosine-protein kinase JAK2(Human)
Lifearc

US Patent
LigandPNGBDBM482249(US10918645, Example 29 | 6-(tetrahydro-2H-pyran- 4...)
Affinity DataIC50: 1.70E+4nMAssay Description:JAK2 (5-20 mU diluted in 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.05% 0-mercaptoethanol, 1 mg/ml BSA) is assayed against PDKtide (KTFCGTPEYLAPEVRREPRILSEEEQ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2021
Entry Details
Go to US Patent