BDBM482239 6-cyclobutyl-6,7,8,9- tetrahydro-2H- 1,2,5,6-tetraazabenzo[cd]azulene::US10918645, Example 22

SMILES C1CC(C1)N1CCCc2n[nH]c3ccnc1c23

InChI Key InChIKey=RPTZIXKKTVIBFN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 482239   

LigandPNGBDBM482239(US10918645, Example 22 | 6-cyclobutyl-6,7,8,9- tet...)
Affinity DataIC50: 140nMAssay Description:TTBK1 (5-20 mU diluted in 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% β-mercaptoethanol, 1 mg/ml BSA, 10 mM DTT) is assayed against RRKDLHDDEEDEAMSITA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Lifearc

US Patent
LigandPNGBDBM482239(US10918645, Example 22 | 6-cyclobutyl-6,7,8,9- tet...)
Affinity DataIC50: 8.40E+3nMAssay Description:JAK2 (5-20 mU diluted in 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.05% 0-mercaptoethanol, 1 mg/ml BSA) is assayed against PDKtide (KTFCGTPEYLAPEVRREPRILSEEEQ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2021
Entry Details
Go to US Patent