BDBM482223 5-Bromo-thiophene-2-sulfonic acid {3-[4-amino-7-(1-methyl-piperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-2-fluoro-phenyl}-amide ::US10918642, Cmpd # 77::US11491158, Cmpd 77

SMILES CN1CCC(CC1)n1cc(-c2cccc(NS(=O)(=O)c3ccc(Br)s3)c2F)c2c(N)ncnc12

InChI Key InChIKey=FLAHJVYFVBKTMH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 482223   

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM482223(US10918642, Cmpd # 77 | 5-Bromo-thiophene-2-sulfon...)
Affinity DataIC50: 33nMAssay Description:Serially diluted compounds were incubated for 60 minutes at room temperature in the presence of ATP/P33 gammaATP mix, substrate and enzyme in a volum...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2021
Entry Details
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TargetEukaryotic translation initiation factor 2-alpha kinase 3 [540-1115](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM482223(US10918642, Cmpd # 77 | 5-Bromo-thiophene-2-sulfon...)
Affinity DataIC50: 33nMAssay Description:The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
Go to US Patent