BDBM482203 5-Bromo-thiophene-2-sulfonic acid [3-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-fluoro-phenyl]-amide ::US10918642, Cmpd # 48::US11491158, Cmpd 48

SMILES Cn1cc(-c2cccc(NS(=O)(=O)c3ccc(Br)s3)c2F)c2c(N)ncnc12

InChI Key InChIKey=NRMMIOPOXOCIKM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 482203   

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM482203(US10918642, Cmpd # 48 | 5-Bromo-thiophene-2-sulfon...)
Affinity DataIC50: 33nMAssay Description:Compounds were 3-fold serially diluted in order to obtain from 3.333 to 0.000169 microM final concentration, then incubated for 60 minutes at room te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2021
Entry Details
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TargetEukaryotic translation initiation factor 2-alpha kinase 3 [540-1115](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM482203(US10918642, Cmpd # 48 | 5-Bromo-thiophene-2-sulfon...)
Affinity DataIC50: 33nMAssay Description:The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
Go to US Patent