BDBM481198 2-((4-(2-(6-Methylpyridin-2-yl)-4,5,6,7-tetrahydro-4,7-ethanopyrazolo[1,5-a]pyridin-3-yl)pyridin-2-yl)amino)ethanol 37::US10906905, Example 37

SMILES Cc1cccc(n1)-c1nc2C3CCC(CC3)n2c1-c1ccnc(NCCO)c1

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 481198   

TargetTGF-beta receptor type-1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM481198(2-((4-(2-(6-Methylpyridin-2-yl)-4,5,6,7-tetrahydro...)
Affinity DataIC50: 52nMAssay Description:TGFβRI kinase assay kit (V4093, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM481198(2-((4-(2-(6-Methylpyridin-2-yl)-4,5,6,7-tetrahydro...)
Affinity DataIC50: 2.91E+3nMAssay Description:VEGFR2: Z′-LYTE Kinase Assay Kit Tyrosine 1 Peptide (PV3190, Invitrogen) was used to assay enzyme activity. 5 μl of recombinant human VEGF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent