BDBM481197 6-(2-(6-Methylpyridin-2-yl)-4,5,6,7-tetrahydro-4,7-ethanopyrazolo[1,5-a]pyridin-3-yl)quinoline-4-carboxamide 36::US10906905, Example 36

SMILES Cc1cccc(n1)-c1nn2C3CCC(CC3)c2c1-c1ccc2nccc(C(N)=O)c2c1

InChI Key InChIKey=NKEPPANSOKDJCW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 481197   

TargetTGF-beta receptor type-1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM481197(6-(2-(6-Methylpyridin-2-yl)-4,5,6,7-tetrahydro-4,7...)
Affinity DataIC50: 21nMAssay Description:TGFβRI kinase assay kit (V4093, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM481197(6-(2-(6-Methylpyridin-2-yl)-4,5,6,7-tetrahydro-4,7...)
Affinity DataIC50: 598nMAssay Description:p38α kinase assay kit (V9591, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM481197(6-(2-(6-Methylpyridin-2-yl)-4,5,6,7-tetrahydro-4,7...)
Affinity DataIC50: 1.01E+3nMAssay Description:VEGFR2: Z′-LYTE Kinase Assay Kit Tyrosine 1 Peptide (PV3190, Invitrogen) was used to assay enzyme activity. 5 μl of recombinant human VEGF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent