BDBM481192 2-(6-Methylpyridin-2-yl)-3-(2-(4-(methylsulfonyl)phenyl)pyridin-4-yl)-4,5,6,7-tetrahydro-4,7-ethanopyrazolo[1,5-a]pyridine 33::US10906905, Example 33

SMILES Cc1cccc(n1)-c1nn2C3CCC(CC3)c2c1-c1ccnc(c1)-c1ccc(cc1)S(C)(=O)=O

InChI Key InChIKey=NXDCVJJDDFFEON-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 481192   

TargetTGF-beta receptor type-1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM481192(2-(6-Methylpyridin-2-yl)-3-(2-(4-(methylsulfonyl)p...)
Affinity DataIC50: 34nMAssay Description:TGFβRI kinase assay kit (V4093, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM481192(2-(6-Methylpyridin-2-yl)-3-(2-(4-(methylsulfonyl)p...)
Affinity DataIC50: 563nMAssay Description:p38α kinase assay kit (V9591, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent