BDBM481188 (5R,8S)-2-(6-Methylpyridin-2-yl)-3-(2-(4-(methylsulfonyl)phenyl)pyridin-4-yl)-5,6,7,8-tetrahydro-5,8-methanoimidazo[1,2-a]pyridine 3-2::US10906905, Example 3-2

SMILES Cc1cccc(n1)-c1nc2[C@H]3CC[C@H](C3)n2c1-c1ccnc(c1)-c1ccc(cc1)S(C)(=O)=O

InChI Key InChIKey=UARGTFDABIYTIP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 481188   

TargetTGF-beta receptor type-1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM481188((5R,8S)-2-(6-Methylpyridin-2-yl)-3-(2-(4-(methylsu...)
Affinity DataIC50: 23nMAssay Description:TGFβRI kinase assay kit (V4093, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM481188((5R,8S)-2-(6-Methylpyridin-2-yl)-3-(2-(4-(methylsu...)
Affinity DataIC50: 654nMAssay Description:p38α kinase assay kit (V9591, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM481188((5R,8S)-2-(6-Methylpyridin-2-yl)-3-(2-(4-(methylsu...)
Affinity DataIC50: 928nMAssay Description:VEGFR2: Z′-LYTE Kinase Assay Kit Tyrosine 1 Peptide (PV3190, Invitrogen) was used to assay enzyme activity. 5 μl of recombinant human VEGF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent