BDBM481180 US10906905, Example 17-1

SMILES Cc1cccc(n1)-c1nc2[C@@H]3CC[C@@H](C3)n2c1-c1ccnc(c1)-c1ccc(cc1)C(=O)NC1CCOCC1

InChI Key InChIKey=QRINOTMCPQYUCC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 481180   

TargetTGF-beta receptor type-1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM481180(US10906905, Example 17-1)
Affinity DataIC50: 28nMAssay Description:TGFβRI kinase assay kit (V4093, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM481180(US10906905, Example 17-1)
Affinity DataIC50: 871nMAssay Description:VEGFR2: Z′-LYTE Kinase Assay Kit Tyrosine 1 Peptide (PV3190, Invitrogen) was used to assay enzyme activity. 5 μl of recombinant human VEGF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent