BDBM481166 2-((4-((5S,8R)-2-(6-Methylpyridin-2-yl)-5,6,7,8-tetrahydro-5,8-methanoimidazo[1,2-a]pyridin-3-yl)pyridin-2-yl)amino)ethanol 5-1::US10906905, Example 5-1

SMILES Cc1cccc(n1)-c1nc2[C@@H]3CC[C@@H](C3)n2c1-c1ccnc(NCCO)c1

InChI Key InChIKey=WGVBWEFONZDSBW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 481166   

TargetTGF-beta receptor type-1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM481166(2-((4-((5S,8R)-2-(6-Methylpyridin-2-yl)-5,6,7,8-te...)
Affinity DataIC50: 46nMAssay Description:TGFβRI kinase assay kit (V4093, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM481166(2-((4-((5S,8R)-2-(6-Methylpyridin-2-yl)-5,6,7,8-te...)
Affinity DataIC50: 3.71E+3nMAssay Description:VEGFR2: Z′-LYTE Kinase Assay Kit Tyrosine 1 Peptide (PV3190, Invitrogen) was used to assay enzyme activity. 5 μl of recombinant human VEGF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
US Patent