BDBM480968 US10906888, Example 185

SMILES O=C(N1CCC2(C1)CCOCC2)c1cnc(NCc2cncnc2)nc1

InChI Key InChIKey=VLUQXQHQMGCAIZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 480968   

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM480968(US10906888, Example 185)
Affinity DataIC50: 7.71nMAssay Description:The test inhibitors were solubilized in DMSO to a stock concentration of 30 mM. On the day of the assay, dose response plates were prepared by diluti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
Go to US Patent

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM480968(US10906888, Example 185)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBiotinidase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480968(US10906888, Example 185)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of N-terminal FLAG/His6-tagged human biotinidase expressed in COS cells using biotinyl-7-amino-4-trifluoromethylcoumarin as substrate prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed