BDBM480929 8-oxa-2-azaspiro[4.5]dec-2-yl(2-{[2-(pyrimidin-5-yl)propan-2-yl]amino}pyrimidin-5-yl)methanone::US10906888, Example 143

SMILES CC(C)(Nc1ncc(cn1)C(=O)N1CCC2(C1)CCOCC2)c1cncnc1

InChI Key InChIKey=AJNRTFNIQNDYTE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 480929   

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM480929(8-oxa-2-azaspiro[4.5]dec-2-yl(2-{[2-(pyrimidin-5-y...)
Affinity DataIC50: 0.0820nMAssay Description:The test inhibitors were solubilized in DMSO to a stock concentration of 30 mM. On the day of the assay, dose response plates were prepared by diluti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2021
Entry Details
Go to US Patent

TargetPantetheinase(Human)
Pfizer

US Patent
LigandPNGBDBM480929(8-oxa-2-azaspiro[4.5]dec-2-yl(2-{[2-(pyrimidin-5-y...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBiotinidase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480929(8-oxa-2-azaspiro[4.5]dec-2-yl(2-{[2-(pyrimidin-5-y...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of N-terminal FLAG/His6-tagged human biotinidase expressed in COS cells using biotinyl-7-amino-4-trifluoromethylcoumarin as substrate prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed