BDBM480500 US10626113, Compound K::US10899756, Compound S

SMILES COc1ccc(Nc2c3CN(CCc3nc3ccc(cc23)C#N)C(C)=O)cc1Cl

InChI Key InChIKey=RQBJLCGXEPTUQE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 480500   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Columbia University

US Patent
LigandPNGBDBM480500(US10899756, Compound S | US10626113, Compound K)
Affinity DataIC50: 593nMAssay Description:A series of dilutions of the test compounds were prepared with 10% DMSO in assay buffer and 5 μl of the dilution was added to a 50 μl react...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
Go to US Patent

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Columbia University

US Patent
LigandPNGBDBM480500(US10899756, Compound S | US10626113, Compound K)
Affinity DataIC50: 593nMAssay Description:Materials and Methods: PDE5 inhibition was assayed at BPS Bioscience (San Diego, Calif.) using BPS PDE assay kits (BPS Catalog number 60300, enzyme l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2023
Entry Details
Go to US Patent