BDBM480488 US10626113, Compound E::US10899756, Compound E

SMILES COc1ccc(CNc2c3c(NCCNC3=O)nc3ccc(cc23)C#N)cc1Cl

InChI Key InChIKey=FECZHVISRNXUCS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 480488   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Columbia University

US Patent
LigandPNGBDBM480488(US10899756, Compound E | US10626113, Compound E)
Affinity DataIC50: 43.8nMAssay Description:A series of dilutions of the test compounds were prepared with 10% DMSO in assay buffer and 5 μl of the dilution was added to a 50 μl react...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
Go to US Patent

TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Human)
Columbia University

US Patent
LigandPNGBDBM480488(US10899756, Compound E | US10626113, Compound E)
Affinity DataIC50: 6.62E+3nMAssay Description:A series of dilutions of the test compounds were prepared with 10% DMSO in assay buffer and 5 μl of the dilution was added to a 50 μl react...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
Go to US Patent

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Columbia University

US Patent
LigandPNGBDBM480488(US10899756, Compound E | US10626113, Compound E)
Affinity DataIC50: 43.8nMAssay Description:Materials and Methods: PDE5 inhibition was assayed at BPS Bioscience (San Diego, Calif.) using BPS PDE assay kits (BPS Catalog number 60300, enzyme l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2023
Entry Details
Go to US Patent

TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Human)
Columbia University

US Patent
LigandPNGBDBM480488(US10899756, Compound E | US10626113, Compound E)
Affinity DataIC50: 6.62E+3nMAssay Description:Materials and Methods: PDE5 inhibition was assayed at BPS Bioscience (San Diego, Calif.) using BPS PDE assay kits (BPS Catalog number 60300, enzyme l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2023
Entry Details
Go to US Patent