BDBM480001 4-(1-Cyclopropyl-3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)-2-(4-(methylsulfonyl)phenyl)pyridine::US10899741, Example 2

SMILES Cc1cccc(n1)-c1nn(cc1-c1ccnc(c1)-c1ccc(cc1)S(C)(=O)=O)C1CC1

InChI Key InChIKey=HIKFXURRIPQGSA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 480001   

TargetTGF-beta receptor type-1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM480001(US10899741, Example 2 | 4-(1-Cyclopropyl-3-(6-meth...)
Affinity DataIC50: 270nMAssay Description:TGFβRI kinase assay kit (V4093, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
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TargetVascular endothelial growth factor receptor 2(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM480001(US10899741, Example 2 | 4-(1-Cyclopropyl-3-(6-meth...)
Affinity DataIC50: 4.20E+3nMAssay Description:VEGFR2: Z'-LYTEC Kinase Assay Kit—Tyrosine 1 Peptide (PV3190, Invitrogen) was used to assay enzyme activity. 5 μl of recombinant human ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
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TargetMitogen-activated protein kinase 14(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM480001(US10899741, Example 2 | 4-(1-Cyclopropyl-3-(6-meth...)
Affinity DataIC50: 1.00E+3nMAssay Description:p38α kinase assay kit (V9591, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
Go to US Patent