BDBM479498 ML300-based SC inhibitor 37::US20240239772, Compound 37

SMILES COc1cc(ccc1-c1cn[nH]c1)N(Cc1cccc(Cl)c1)C(=O)Cn1nnc2ccccc12

InChI Key InChIKey=ZUSJSFVCQUBXFQ-UHFFFAOYSA-N

Data  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 479498   

TargetReplicase polyprotein 1ab(SARS-CoV)
Cleveland Clinic

LigandPNGBDBM479498(ML300-based SC inhibitor 37 | US20240239772, Compo...)
Affinity DataIC50: 206nMAssay Description:The protease activity and subsequent 10-point IC50 curves were spectroscopically determined using a scaled down, end point assay adapted from a previ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cleveland Clinic

LigandPNGBDBM479498(ML300-based SC inhibitor 37 | US20240239772, Compo...)
Affinity DataIC50: 328nMAssay Description:The protease activity and subsequent 10-point IC50 curves were spectroscopically determined using a scaled down, end point assay adapted from a previ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cleveland Clinic

LigandPNGBDBM479498(ML300-based SC inhibitor 37 | US20240239772, Compo...)
Affinity DataEC50:  2.93E+3nMAssay Description:Briefly, Vero E6 ACE2 cells were cultured in 96-well flat-bottom plates at a density of 2 × 104 cells per well. Following infection of the cells with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cleveland Clinic

LigandPNGBDBM479498(ML300-based SC inhibitor 37 | US20240239772, Compo...)
Affinity DataEC50:  3.24E+3nMAssay Description:Confluent monolayers of Vero E6 ACE2 cells in 12-well plates were washed once with DMEM and infected with approximately 50 plaque forming units (PFUs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
Cleveland Clinic

LigandPNGBDBM479498(ML300-based SC inhibitor 37 | US20240239772, Compo...)
Affinity DataIC50: 206nMAssay Description:Protease activity and subsequent 10-point IC50 curves were spectroscopically determined using a scaled down, endpoint assay adapted from a previously...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2024
Entry Details
Go to US Patent

TargetReplicase polyprotein 1ab(2019-nCoV)
Cleveland Clinic

LigandPNGBDBM479498(ML300-based SC inhibitor 37 | US20240239772, Compo...)
Affinity DataIC50: 328nMAssay Description:Protease activity and subsequent 10-point IC50 curves were spectroscopically determined using a scaled down, endpoint assay adapted from a previously...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2024
Entry Details
Go to US Patent