BDBM479346 (3-((3S,4S)-4-amino-3-methyl- 2-oxa-8-azaspiro[4.5]decan- 8-yl)-6-(((S)-2-amino-6a,7,8,9-tetrahydro- 6H-pyrido[3,2-b]pyrrolo[1,2-d][1,4]oxazin-4- yl)thio)pyrazin-2-yl)methanol formate::US10894797, Compound 35::US11034705, Compound 35::US11518772, Compound 35

SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3cc(N)nc4N5CCC[C@H]5COc34)nc2CO)[C@@H]1N

InChI Key InChIKey=VKQWFSBYDFOYLI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 479346   

TargetSH2B adapter protein 2(Human)
Nikang Therapeutics

US Patent
LigandPNGBDBM479346((3-((3S,4S)-4-amino-3-methyl- 2-oxa-8-azaspiro[4.5...)
Affinity DataIC50: 18nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Nikang Therapeutics

US Patent
LigandPNGBDBM479346((3-((3S,4S)-4-amino-3-methyl- 2-oxa-8-azaspiro[4.5...)
Affinity DataIC50: 18nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Nikang Therapeutics

US Patent
LigandPNGBDBM479346((3-((3S,4S)-4-amino-3-methyl- 2-oxa-8-azaspiro[4.5...)
Affinity DataIC50: 18nMAssay Description:SHP2 possesses two N-terminal Src homology 2 (SH2) domains, a central protein-tyrosine phosphatase (PTP) domain, and C-terminal tail. At the basal st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
US Patent