BDBM478031 BDBM50279688::US10889592, Compound I-12::US11325917, Compound I-12

SMILES C[C@H](CNC(=O)c1sc2nc(C)cnc2c1N)c1ccc(N2CC3CCC(C2)N3)c(F)c1

InChI Key InChIKey=HGSLLSJZVGUOGE-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 478031   

TargetUbiquitin carboxyl-terminal hydrolase 25(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM478031(US10889592, Compound I-12 | BDBM50279688 | US11325...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of recombinant human His6-tagged USP25 expressed in baculovirus infected Sf21 insect cells using Ub-Rh110 as substrate pretreated for 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2020
Entry Details Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 28(Human)
Valo Early Discovery

US Patent
LigandPNGBDBM478031(US10889592, Compound I-12 | BDBM50279688 | US11325...)
Affinity DataIC50: 1.10E+3nMAssay Description:USP28: Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Cor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetUbiquitin carboxyl-terminal hydrolase 25(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM478031(US10889592, Compound I-12 | BDBM50279688 | US11325...)
Affinity DataIC50: 6.00E+3nMAssay Description:USP25: The assay was performed in a final volume of 9 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetUbiquitin carboxyl-terminal hydrolase 28(Human)
Valo Early Discovery

US Patent
LigandPNGBDBM478031(US10889592, Compound I-12 | BDBM50279688 | US11325...)
Affinity DataIC50: 1.10E+3nMAssay Description:Ubiquitin-Rhodamine 110 Assay for USP28 Activity: Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2022
Entry Details
Go to US Patent

TargetUbiquitin carboxyl-terminal hydrolase 25(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM478031(US10889592, Compound I-12 | BDBM50279688 | US11325...)
Affinity DataIC50: 6.00E+3nMAssay Description:Ubiquitin-Rhodamine 110 Assay for USP25 Activity: The assay was performed in a final volume of 9 μL in assay buffer containing 20 mM Tris-HCl (p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2022
Entry Details
Go to US Patent