BDBM477931 (1S,5S)-5-(5-((5-chloro-3-methylpyridin-2-yl)ethynyl)-2-fluorophenyl)-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-3-amine::US10889581, Example 134

SMILES COC[C@]12CC1[C@](C)(N=C(N)S2)c1cc(ccc1F)C#Cc1ncc(Cl)cc1C

InChI Key InChIKey=WRIHTLGFUKBBKQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 477931   

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477931(US10889581, Example 134 | (1S,5S)-5-(5-((5-chloro-...)
Affinity DataIC50: 129nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Human)
Amgen

US Patent
LigandPNGBDBM477931(US10889581, Example 134 | (1S,5S)-5-(5-((5-chloro-...)
Affinity DataIC50: 613nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetCathepsin D(Human)
Amgen

US Patent
LigandPNGBDBM477931(US10889581, Example 134 | (1S,5S)-5-(5-((5-chloro-...)
Affinity DataIC50: 4.00E+5nMAssay Description:Recombinant CatD was expressed in CHO cells. The assay buffer for CatD was 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent