BDBM477902 (1S,5S,6S)-5-(5-((5-(but-2-yn-1-yloxy)pyridin-2-yl)ethynyl)-2-fluorophenyl)-1,5-bis(fluoromethyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-3-amine::US10889581, Example 105

SMILES CC#CCOc1ccc(nc1)C#Cc1ccc(F)c(c1)[C@@]1(CF)N=C(N)S[C@@]2(CF)C[C@@H]12

InChI Key InChIKey=FWQMUIPDWBVIAK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 477902   

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477902(US10889581, Example 105 | (1S,5S,6S)-5-(5-((5-(but...)
Affinity DataIC50: 96nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Human)
Amgen

US Patent
LigandPNGBDBM477902(US10889581, Example 105 | (1S,5S,6S)-5-(5-((5-(but...)
Affinity DataIC50: 1.03E+4nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetCathepsin D(Human)
Amgen

US Patent
LigandPNGBDBM477902(US10889581, Example 105 | (1S,5S,6S)-5-(5-((5-(but...)
Affinity DataIC50: 5.00E+5nMAssay Description:Recombinant CatD was expressed in CHO cells. The assay buffer for CatD was 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent