BDBM477619 (R) N-(1-(2-fluoro-5-methylphenyl)-4,5,6,7-tetrahydro-1H-indazol-4-yl)-4,5,6,7-tetrahydrobenzo[c]isoxazole-3-carboxamide::US10889564, Example 49

SMILES Cc1ccc(F)c(c1)-n1ncc2[C@@H](CCCc12)NC(=O)c1onc2CCCCc12

InChI Key InChIKey=QCYACHGROOAKHF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 477619   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Genase Therapeutics

US Patent
LigandPNGBDBM477619(US10889564, Example 49 | (R) N-(1-(2-fluoro-5-meth...)
Affinity DataIC50: 17nMAssay Description:Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Genase Therapeutics

US Patent
LigandPNGBDBM477619(US10889564, Example 49 | (R) N-(1-(2-fluoro-5-meth...)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed