BDBM477572 N-(1-(2-Fluorophenyl)-4,5,6,7-tetrahydro-1H-indazol-4-yl)picolinamide::US10889564, Example 1

SMILES Fc1ccccc1-n1ncc2C(CCCc12)NC(=O)c1ccccn1

InChI Key InChIKey=NVQPQLKFUOFZLS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 477572   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Genase Therapeutics

US Patent
LigandPNGBDBM477572(US10889564, Example 1 | N-(1-(2-Fluorophenyl)-4,5,...)
Affinity DataIC50: 2.17E+3nMAssay Description:Assay A: DHODH enzyme assays were performed with 6 nM recombinant human DHODH (purified essentially as described by Walse et. al., Biochemistry, 47, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Genase Therapeutics

US Patent
LigandPNGBDBM477572(US10889564, Example 1 | N-(1-(2-Fluorophenyl)-4,5,...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged DHODH (31 to 395 residues) expressed in Escherichia coli expression system using dihydroorotic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed