BDBM477065 US10882859, Reference compound PF-06263276

SMILES CCc1cc(O)c(F)cc1-c1ccc2c(n[nH]c2c1)-c1nc2CCN(Cc2[nH]1)C(=O)c1cnc(cn1)N1CCCCC1

InChI Key InChIKey=XDJGNPSZQSWJCV-UHFFFAOYSA-N

Data  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 477065   

TargetTyrosine-protein kinase JAK1(Human)
Topivert Pharma

US Patent
LigandPNGBDBM477065(US10882859, Reference compound PF-06263276)
Affinity DataKd:  2.70nMAssay Description:The biochemical JAK family enzyme binding assays carried out at DiscoveRx.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Topivert Pharma

US Patent
LigandPNGBDBM477065(US10882859, Reference compound PF-06263276)
Affinity DataKd:  0.780nMAssay Description:The biochemical JAK family enzyme binding assays carried out at DiscoveRx.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Topivert Pharma

US Patent
LigandPNGBDBM477065(US10882859, Reference compound PF-06263276)
Affinity DataKd:  1.90nMAssay Description:The biochemical JAK family enzyme binding assays carried out at DiscoveRx.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Topivert Pharma

US Patent
LigandPNGBDBM477065(US10882859, Reference compound PF-06263276)
Affinity DataKd:  1.90nMAssay Description:The biochemical JAK family enzyme binding assays carried out at DiscoveRx.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
Go to US Patent