BDBM477059 US10882857, Example 3::US11673888, Example 3::[2-Cyclopropyl-6-(oxan-4-ylmethoxy)pyridin-4-yl]-[2-(3-hydroxy-5,7-dihydro-4H-[1,2]oxazolo[5,4-c]pyridine-6-carbonyl)-4,6-dihydropyrrolo[3,4-d][1,3]oxazol-5-yl]methanone

SMILES Oc1noc2CN(CCc12)C(=O)c1nc2CN(Cc2o1)C(=O)c1cc(OCC2CCOCC2)nc(c1)C1CC1

InChI Key InChIKey=JMDGGLSPJJFLOY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 477059   

TargetAutotaxin(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM477059(US10882857, Example 3 | [2-Cyclopropyl-6-(oxan-4-y...)
Affinity DataIC50: 5nMAssay Description:Assay buffer (50 mM Tris-HCl, 140 mM NaCl, 5 mM KCl, 1 mM CaCl2, 1 mM MgCl2, 0.01% Triton-X-100, pH 8.0;ATX solution: ATX (human His-tagged) stock so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
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TargetAutotaxin(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM477059(US10882857, Example 3 | [2-Cyclopropyl-6-(oxan-4-y...)
Affinity DataIC50: 5nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent