BDBM477055 US10882857, Example 2.03::US11673888, Example 2.03

SMILES CC(C)(C)C(=O)Nc1cc(cnc1COC(=O)N1Cc2ccc(cc2C1)C(=O)N1CCC(CC1)S(N)(=O)=O)C(F)(F)F

InChI Key InChIKey=KMPSIXQBOAMPFM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 477055   

TargetAutotaxin(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM477055(US10882857, Example 2.03 | US11673888, Example 2.0...)
Affinity DataIC50: 7nMAssay Description:Assay buffer (50 mM Tris-HCl, 140 mM NaCl, 5 mM KCl, 1 mM CaCl2, 1 mM MgCl2, 0.01% Triton-X-100, pH 8.0;ATX solution: ATX (human His-tagged) stock so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
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TargetAutotaxin(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM477055(US10882857, Example 2.03 | US11673888, Example 2.0...)
Affinity DataIC50: 7nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent