BDBM477054 US10882857, Example 2.02::US11673888, Example 2.02

SMILES c1cc2c(cc1C(=O)N3CCc4c(c(no4)O)C3)CN(C2)C(=O)c5cc(nc(c5)OCC6CCOCC6)C7CC7

InChI Key InChIKey=KUILTMRZKQDPSS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 477054   

TargetAutotaxin(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM477054(US10882857, Example 2.02 | US11673888, Example 2.0...)
Affinity DataIC50: 7nMAssay Description:Assay buffer (50 mM Tris-HCl, 140 mM NaCl, 5 mM KCl, 1 mM CaCl2, 1 mM MgCl2, 0.01% Triton-X-100, pH 8.0;ATX solution: ATX (human His-tagged) stock so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
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TargetAutotaxin(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM477054(US10882857, Example 2.02 | US11673888, Example 2.0...)
Affinity DataIC50: 7nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent