BDBM476981 Inhibitor 4 of SARS-CoV-2 Mpro::US20240092759, Compound 47

SMILES FC(F)(F)CCOc1cc(Cl)cc(c1)-c1cc(cn(-c2cccnc2)c1=O)-c1ccccc1C#N

InChI Key InChIKey=GHBWVWMKFOCWLG-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 476981   

TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM476981(Inhibitor 4 of SARS-CoV-2 Mpro | US20240092759, Co...)
Affinity DataIC50: 120nMAssay Description:Purified protein is diluted in reaction buffer to 100 nM in an opaque 96-well plate. The protein is incubated with or without compound in DMSO at dif...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM476981(Inhibitor 4 of SARS-CoV-2 Mpro | US20240092759, Co...)
Affinity DataEC50:  1.20E+3nMAssay Description:These include a rapid screening replicon assay using baby hamster kidney (BHK) cells with noninfectious SARS-CoV-2, in which the spike protein in the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM476981(Inhibitor 4 of SARS-CoV-2 Mpro | US20240092759, Co...)
Affinity DataEC50:  1.10E+3nMAssay Description:These assays are from various references.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1a(2019-nCoV)
Yale University

US Patent
LigandPNGBDBM476981(Inhibitor 4 of SARS-CoV-2 Mpro | US20240092759, Co...)
Affinity DataIC50: 120nMAssay Description:Inhibition of proteolytic activity was tested using recombinant SARS-Cov-2 Mpro, as described herein in the Experimental section. For the kinetic ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
Go to US Patent