BDBM476706 3-(5-chloro-2-((3-cyclopropyl-5-(((3R,5S)-3,5-dimethylpiperazine-1-yl)methyl)phenyl)amino)pyrimidine-4-yl)-6-methyl-1H-indole-5-ol::US10870639, Example 18::US11292786, Example 18

SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(C)c(O)cc34)cc(c2)C2CC2)C[C@@H](C)N1

InChI Key InChIKey=VFMHXEDMHPOOPS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 476706   

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM476706(3-(5-chloro-2-((3-cyclopropyl-5-(((3R,5S)-3,5-dime...)
Affinity DataIC50: 13nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2021
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM476706(3-(5-chloro-2-((3-cyclopropyl-5-(((3R,5S)-3,5-dime...)
Affinity DataIC50: 3.70nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2021
Entry Details
Go to US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM476706(3-(5-chloro-2-((3-cyclopropyl-5-(((3R,5S)-3,5-dime...)
Affinity DataIC50: 13nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM476706(3-(5-chloro-2-((3-cyclopropyl-5-(((3R,5S)-3,5-dime...)
Affinity DataIC50: 3.70nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
Go to US Patent