BDBM476701 US10870639, Example 10::US11292786, Example 10::chloro-N-(3-cyclopropyl-5-((3,5-dimethyl piperazine-1-yl)methyl)phenyl)-4-(6-methyl-1H-indole-3-yl)pyrimidine-2-amine

SMILES CC1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(C)ccc34)cc(c2)C2CC2)CC(C)N1

InChI Key InChIKey=FZLSDZZNPXXBBB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 476701   

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM476701(chloro-N-(3-cyclopropyl-5-((3,5-dimethyl piperazin...)
Affinity DataIC50: 3.60nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2021
Entry Details
Go to US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM476701(chloro-N-(3-cyclopropyl-5-((3,5-dimethyl piperazin...)
Affinity DataIC50: 3.60nMAssay Description:The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
Go to US Patent