BDBM476688 (R)-3-Imino-2,2,5-trimethyl-5-(8- (prop-1-yn-1-yl)dibenzo[b,d]thiophen- 2-yl)thiomorpholine 1,1-dioxide::US10870635, Example 103

SMILES CC#Cc1ccc2sc3ccc(cc3c2c1)[C@]1(C)CS(=O)(=O)C(C)(C)C(=N)N1

InChI Key InChIKey=TYFDPTNOAQWDOO-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 476688   

TargetBeta-secretase 2(Human)
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476688(US10870635, Example 103 | (R)-3-Imino-2,2,5-trimet...)
Affinity DataIC50: 12nMAssay Description:A BACE2 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected compounds by AnaSpec BACE2 fluorescent as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2021
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476688(US10870635, Example 103 | (R)-3-Imino-2,2,5-trimet...)
Affinity DataIC50: 39nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2021
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476688(US10870635, Example 103 | (R)-3-Imino-2,2,5-trimet...)
Affinity DataIC50: 39nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2021
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476688(US10870635, Example 103 | (R)-3-Imino-2,2,5-trimet...)
Affinity DataIC50: 39nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2021
Entry Details
US Patent

TargetCathepsin D(Human)
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476688(US10870635, Example 103 | (R)-3-Imino-2,2,5-trimet...)
Affinity DataIC50: 1.72E+4nMAssay Description:Cathepsin D (Cat D) is a major intercellular member of the mammalian aspartic proteinase family and is thought to be in the normal degradation of int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2021
Entry Details
US Patent