BDBM476652 (2S,4R)-1-[(2S)-2-[(5-Chlorothiophen-2-yl)sulfonylamino]-3-methoxypropanoyl]-4-[(4-methoxyphenyl)methylsulfonyl]-N-[(3S)-1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl]pyrrolidine-2-carboxamide::US10870623, Example 19

SMILES COC[C@H](NS(=O)(=O)c1ccc(Cl)s1)C(=O)N1C[C@@H](C[C@H]1C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F)S(=O)(=O)Cc1ccc(OC)cc1

InChI Key InChIKey=ZPFIDCBASUDYBO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 476652   

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM476652((2S,4R)-1-[(2S)-2-[(5-Chlorothiophen-2-yl)sulfonyl...)
Affinity DataIC50: 14.8nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
Go to US Patent