BDBM476220 US10865384, Compound SB431542::US11447490, Compound SB431542::US11466003, Compound SB431542

SMILES NC(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccccn1)-c1ccc2OCOc2c1

InChI Key InChIKey=FHYUGAJXYORMHI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 476220   

TargetCasein kinase I isoform delta(Human)
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM476220(US10865384, Compound SB431542 | US11466003, Compou...)
Affinity DataIC50: 174nMAssay Description:Table 3: Small molecules were tested for their inhibitory activities towards casein kinase 1 delta (CK1δ) and 1 epsilon (CK1ϵ). The in vit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2021
Entry Details
Go to US Patent

TargetCasein kinase I isoform epsilon(Human)
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM476220(US10865384, Compound SB431542 | US11466003, Compou...)
Affinity DataIC50: 147nMAssay Description:Table 3: Small molecules were tested for their inhibitory activities towards casein kinase 1 delta (CK1δ) and 1 epsilon (CK1ϵ). The in vit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2021
Entry Details
Go to US Patent

TargetTGF-beta receptor type-1(Human)
Shanghai Yingli Pharmaceutical

US Patent
LigandPNGBDBM476220(US10865384, Compound SB431542 | US11466003, Compou...)
Affinity DataIC50: 108nMAssay Description:1. Preparation of kinase buffer: 40 mM Tris (pH 7.5), 20 mM MgCl2, 0.10% BSA, 1 mM DTT.2. Preparation of the compound: the final concentration of the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
Go to US Patent

TargetTGF-beta receptor type-1(Human)
Shanghai Yingli Pharmaceutical

US Patent
LigandPNGBDBM476220(US10865384, Compound SB431542 | US11466003, Compou...)
Affinity DataIC50: 108nMAssay Description:1. Preparation of a 1× kinase buffer: 40 mM Tris (pH 7.5), 20 mM MgCl2, 0.10% BSA, 1 mM DTT.2. Compound preparation: The final detection concentratio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
Go to US Patent