BDBM476219 US10865384, Compound D4476::US11633415, Compound D-4476::US11759530, Compound Table1.3::US12215095, Compound D4476

SMILES NC(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccccn1)-c1ccc2OCCOc2c1

InChI Key InChIKey=DPDZHVCKYBCJHW-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 476219   

TargetCasein kinase I isoform delta(Human)
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM476219(US10865384, Compound D4476 | US11633415, Compound ...)
Affinity DataIC50: 157nMAssay Description:Table 3: Small molecules were tested for their inhibitory activities towards casein kinase 1 delta (CK1δ) and 1 epsilon (CK1ϵ). The in vit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2021
Entry Details
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TargetCasein kinase I isoform epsilon(Human)
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM476219(US10865384, Compound D4476 | US11633415, Compound ...)
Affinity DataIC50: 88nMAssay Description:Table 3: Small molecules were tested for their inhibitory activities towards casein kinase 1 delta (CK1δ) and 1 epsilon (CK1ϵ). The in vit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2021
Entry Details
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TargetCasein kinase I isoform alpha(Human)
The Broad Institute

US Patent
LigandPNGBDBM476219(US10865384, Compound D4476 | US11633415, Compound ...)
Affinity DataIC50: 321nMAssay Description:In order to identify inhibitors of CSNK1A1, the CSNK1A1 knockdown signatures in CMap were compared to all CMap compound signatures, and resultant com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
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TargetTGF-beta receptor type-1(Human)
City of Hope

US Patent
LigandPNGBDBM476219(US10865384, Compound D4476 | US11633415, Compound ...)
Affinity DataIC50: 500nMAssay Description:No assay is defined.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2023
Entry Details
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TargetMitogen-activated protein kinase 14(Human)
City of Hope

US Patent
LigandPNGBDBM476219(US10865384, Compound D4476 | US11633415, Compound ...)
Affinity DataIC50: 1.20E+7nMAssay Description:No assay is defined.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2023
Entry Details
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TargetCasein kinase I isoform delta(Human)
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM476219(US10865384, Compound D4476 | US11633415, Compound ...)
Affinity DataIC50: 3.00E+5nMAssay Description:No assay is defined.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2023
Entry Details
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TargetCasein kinase I homolog hhp1(Fission yeast)
City of Hope

US Patent
LigandPNGBDBM476219(US10865384, Compound D4476 | US11633415, Compound ...)
Affinity DataIC50: 200nMAssay Description:No assay is defined.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2023
Entry Details
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TargetGlycogen synthase kinase-3(Human)
City of Hope

US Patent
LigandPNGBDBM476219(US10865384, Compound D4476 | US11633415, Compound ...)
Affinity DataIC50: 10nMAssay Description:No assay is defined.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2023
Entry Details
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TargetCyclin-dependent kinase 5 activator 1 [99-307](Human)
City of Hope

US Patent
LigandPNGBDBM476219(US10865384, Compound D4476 | US11633415, Compound ...)
Affinity DataIC50: 2.40E+7nMAssay Description:No assay is defined.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2023
Entry Details
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TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
City of Hope

US Patent
LigandPNGBDBM476219(US10865384, Compound D4476 | US11633415, Compound ...)
Affinity DataIC50: 4.30E+7nMAssay Description:No assay is defined.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2023
Entry Details
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LigandPNGBDBM476219(US10865384, Compound D4476 | US11633415, Compound ...)
Affinity DataIC50: 320nMAssay Description:No assay is defined.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2023
Entry Details
Go to US Patent

TargetGlycogen synthase kinase-3(Human)
City of Hope

US Patent
LigandPNGBDBM476219(US10865384, Compound D4476 | US11633415, Compound ...)
Affinity DataIC50: 10nMAssay Description:No assay is defined.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2023
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 5 activator 1 [99-307](Human)
City of Hope

US Patent
LigandPNGBDBM476219(US10865384, Compound D4476 | US11633415, Compound ...)
Affinity DataIC50: 2.40E+7nMAssay Description:No assay is defined.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2023
Entry Details
Go to US Patent

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
City of Hope

US Patent
LigandPNGBDBM476219(US10865384, Compound D4476 | US11633415, Compound ...)
Affinity DataIC50: 4.30E+7nMAssay Description:No assay is defined.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2023
Entry Details
Go to US Patent

TargetCasein kinase I isoform delta(Human)
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM476219(US10865384, Compound D4476 | US11633415, Compound ...)
Affinity DataIC50: 214nMAssay Description:The assay used was the HotSpot assay (Reaction Biology Corp).Compounds were tested in 10-dose IC50 mode with a 3-fold serial dilution starting at 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2025
Entry Details
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