BDBM475676 1-(6-(2-hydroxy-2-(4-methyl-1-oxo- 1,3-dihydroisobenzofuran-5-yl)ethyl)- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin- 2-yl)-1H-pyrazole-4-carbonitrile (Enantiomer-I)::US10851108, Example 56-I

SMILES Cc1c2COC(=O)c2ccc1C(O)CN1CCc2nc(ncc2C1)-n1cc(cn1)C#N

InChI Key InChIKey=LUDUGDBSNJKSHW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 475676   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM475676(1-(6-(2-hydroxy-2-(4-methyl-1-oxo- 1,3-dihydroisob...)
Affinity DataIC50: 12nMAssay Description:The coverslip plated with cells was placed in the experiment chamber perfused with bath solution composed of (in mM): 135 NaCl, 5 KCl, 2 CaCl2, 1 MgC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent