BDBM475670 N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3′-oxo-2′,3′-dihydro-1′H-spiro [cyclopropane-1,4′-[2,7]naphthyridine]-6′-ylamino)-4-(4-methylpiperazin-1-yl)phenyl)acrylamide::US10851105, Example 11

SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4cc(ccc4NC(=O)C=C)N4CCN(C)CC4)cc3C3(CC3)C2=O)c1F

InChI Key InChIKey=FSGGEVVZGGOLIG-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 475670   

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM475670(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
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TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM475670(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM475670(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Affinity DataIC50: 200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent
LigandPNGBDBM475670(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM475670(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Affinity DataIC50: 200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM475670(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Affinity DataIC50: 200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM475670(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Affinity DataIC50: 200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent
LigandPNGBDBM475670(N-(2-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-...)
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
Go to US Patent