BDBM475667 N-(2-(2-(2,6-difluoro-3,5-dimethoxyphenyl)-3-oxo-2,2′,3,3′,5′,6′-hexahydro-1H-spiro[[2,7]naphthyridine-4,4′-pyran]-6-ylamino)phenyl)acrylamide::US10851105, Example 8

SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)cc3C3(CCOCC3)C2=O)c1F

InChI Key InChIKey=XKIRUVCZIBXSNM-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 475667   

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM475667(N-(2-(2-(2,6-difluoro-3,5-dimethoxyphenyl)-3-oxo-2...)
Affinity DataIC50: 200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM475667(N-(2-(2-(2,6-difluoro-3,5-dimethoxyphenyl)-3-oxo-2...)
Affinity DataIC50: 200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM475667(N-(2-(2-(2,6-difluoro-3,5-dimethoxyphenyl)-3-oxo-2...)
Affinity DataIC50: 200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent
LigandPNGBDBM475667(N-(2-(2-(2,6-difluoro-3,5-dimethoxyphenyl)-3-oxo-2...)
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM475667(N-(2-(2-(2,6-difluoro-3,5-dimethoxyphenyl)-3-oxo-2...)
Affinity DataIC50: 200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM475667(N-(2-(2-(2,6-difluoro-3,5-dimethoxyphenyl)-3-oxo-2...)
Affinity DataIC50: 200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM475667(N-(2-(2-(2,6-difluoro-3,5-dimethoxyphenyl)-3-oxo-2...)
Affinity DataIC50: 200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent
LigandPNGBDBM475667(N-(2-(2-(2,6-difluoro-3,5-dimethoxyphenyl)-3-oxo-2...)
Affinity DataIC50: 200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
Go to US Patent