BDBM475661 N-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3′-oxo-2′,3′-dihydro-1′H-spiro [cyclopropane-1,4′-[2,7]naphthyridine]-6′-yl)-N-methylacrylamide::US10851105, Example 2

SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)N(C)C(=O)C=C)c1F

InChI Key InChIKey=ULMGILFSLBVEHM-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 475661   

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM475661(N-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&#...)
Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM475661(N-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&#...)
Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM475661(N-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&#...)
Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent
LigandPNGBDBM475661(N-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&#...)
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM475661(N-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&#...)
Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM475661(N-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&#...)
Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM475661(N-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&#...)
Affinity DataIC50: 200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent
LigandPNGBDBM475661(N-(2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3&#...)
Affinity DataIC50: 20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
Go to US Patent