BDBM475604 US10851092, Example 5

SMILES COc1cc2cc(cnc2cc1OC)-c1ccc(CC(=O)Nc2cc(n[nH]2)C(C)(C)C(F)(F)F)cn1

InChI Key InChIKey=CRTJKIZFZVCHSV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 475604   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Daiichi Sankyo

US Patent
LigandPNGBDBM475604(US10851092, Example 5)
Affinity DataIC50: 2.20nMAssay Description:A reaction buffer (100 mM HEPES (pH 7.4), 10 mM MgCl2, 0.003% Brij-35, 0.004% Tween-20, and 1 mM DTT) was mixed with a RET recombinant protein (RET w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
Go to US Patent

LigandPNGBDBM475604(US10851092, Example 5)
Affinity DataIC50: 2.70nMAssay Description:A reaction buffer (100 mM HEPES (pH 7.4), 10 mM MgCl2, 0.003% Brij-35, 0.004% Tween-20, and 1 mM DTT) was mixed with a RET recombinant protein (RET w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
Go to US Patent