BDBM475581 US10851089, Compound FC-11

SMILES CCCC1(NC(=O)NC1=O)c1occc1Sc1ccc(OCc2cccc(C)c2)cc1

InChI Key InChIKey=XIOAXXPLGOGEIS-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 475581   

TargetMacrophage metalloelastase(Human)
Foresee Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 475581BDBM475581(US10851089, Compound FC-11)
Affinity DataIC50: 10nMAssay Description:The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

TargetStromelysin-1(Human)
Foresee Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 475581BDBM475581(US10851089, Compound FC-11)
Affinity DataIC50: 550nMAssay Description:The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

TargetCollagenase 3(Human)
Foresee Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 475581BDBM475581(US10851089, Compound FC-11)
Affinity DataIC50: 5.50E+3nMAssay Description:The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

TargetMatrix metalloproteinase-14(Human)
Foresee Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 475581BDBM475581(US10851089, Compound FC-11)
Affinity DataIC50: 5.50E+3nMAssay Description:The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

Target72 kDa type IV collagenase(Human)
Foresee Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 475581BDBM475581(US10851089, Compound FC-11)
Affinity DataIC50: 5.50E+3nMAssay Description:The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

TargetNeutrophil collagenase(Human)
Foresee Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 475581BDBM475581(US10851089, Compound FC-11)
Affinity DataIC50: 5.50E+3nMAssay Description:The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

TargetMatrix metalloproteinase-9(Human)
Foresee Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 475581BDBM475581(US10851089, Compound FC-11)
Affinity DataIC50: 5.50E+3nMAssay Description:The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

TargetStromelysin-2(Human)
Foresee Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 475581BDBM475581(US10851089, Compound FC-11)
Affinity DataIC50: 5.50E+3nMAssay Description:The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

TargetInterstitial collagenase(Human)
Foresee Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 475581BDBM475581(US10851089, Compound FC-11)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

TargetMatrilysin(Human)
Foresee Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 475581BDBM475581(US10851089, Compound FC-11)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent