BDBM475166 US10851082, NUCC-0060954

SMILES C(Cc1ccncc1)Nc1nccc(n1)-n1ccc2ccccc12

InChI Key InChIKey=JGVADCMKSSEOQF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 475166   

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 475166BDBM475166(US10851082, NUCC-0060954)
Affinity DataIC50: 4.00E+3nMAssay Description:The synthesized compounds then were tested for inhibition of the kinase activity (IC50) of Mnk1 and/or Mnk2 using the ADP monitoring assay for kinase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 475166BDBM475166(US10851082, NUCC-0060954)
Affinity DataIC50: 4.00E+3nMAssay Description:The synthesized compounds then were tested for inhibition of the kinase activity (IC50) of Mnk1 and/or Mnk2 using the ADP monitoring assay for kinase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 475166BDBM475166(US10851082, NUCC-0060954)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of full length GST-tagged human recombinant MNK2 expressed in insect cells using GRSRSRSRSR as substrate incubated for 30 min by ADP-Glo k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Northwestern University

US Patent
LigandChemical structure of BindingDB Monomer ID 475166BDBM475166(US10851082, NUCC-0060954)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of full length GST-tagged human recombinant MNK1 expressed in insect cells using GRSRSRSRSR as substrate incubated for 30 min in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed