BDBM474837 US10849883, Compound 263a::US11559515, Compound 263a

SMILES CC(C)(C)NC(=O)Nc1ccc2n(CC(=O)N(CC(=O)NCc3cccc(Cl)c3F)C3CC3)nc(C(N)=O)c2c1

InChI Key InChIKey=GMYHAAHBTSBLRX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 474837   

TargetComplement factor D(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM474837(US10849883, Compound 263a | US11559515, Compound 2...)
Affinity DataIC50: 87nMAssay Description:Inhibition of human complement factor D using Z-L-Lys-SBzl hydrochloride as substrate preincubated for 15 mins followed by substrate addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetComplement factor D(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM474837(US10849883, Compound 263a | US11559515, Compound 2...)
Affinity DataIC50: 1.00E+3nMAssay Description:An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

TargetComplement factor D(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM474837(US10849883, Compound 263a | US11559515, Compound 2...)
Affinity DataIC50: 1.00E+4nMAssay Description:An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent