BDBM474615 US10849883, Compound 44f::US11559515, Compound 44f

SMILES NC(=O)c1nn(CC(=O)N(CCCO)CC(=O)NCc2cccc(Cl)c2F)c2ccccc12

InChI Key InChIKey=KQBVPKAUZXITDR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 474615   

TargetComplement factor D(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM474615(US10849883, Compound 44f | US11559515, Compound 44...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human complement factor D using Z-L-Lys-SBzl hydrochloride as substrate preincubated for 15 mins followed by substrate addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetComplement factor D(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM474615(US10849883, Compound 44f | US11559515, Compound 44...)
Affinity DataIC50: 5.50E+3nMAssay Description:An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

TargetComplement factor D(Human)
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM474615(US10849883, Compound 44f | US11559515, Compound 44...)
Affinity DataIC50: 5.50E+3nMAssay Description:An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent