BDBM474416 1,1,1,3,3,3-Hexafluoropropan-2-yl 2-{[6-(difluoromethyl)pyridin-3-yl]oxy}-7-azaspiro[3.5]nonane-7-carboxylate ::US10858373, Example 14

SMILES FC(F)c1ccc(OC2CC3(C2)CCN(CC3)C(=O)OC(C(F)(F)F)C(F)(F)F)cn1

InChI Key InChIKey=BNWWKJLMYVIPBW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 474416   

TargetMonoglyceride lipase(Human)
Pfizer

US Patent
LigandPNGBDBM474416(US10858373, Example 14 | 1,1,1,3,3,3-Hexafluoropro...)
Affinity DataIC50: 3.63nMAssay Description:Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Pfizer

US Patent
LigandPNGBDBM474416(US10858373, Example 14 | 1,1,1,3,3,3-Hexafluoropro...)
Affinity DataIC50: 0.942nMAssay Description:T = 30 minutes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent