BDBM474414 1,1,1,3,3,3-Hexafluoropropan-2-yl (3R)-3-(4-fluoro-1H-pyrazol-1-yl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate ::US10858373, Example 12

SMILES Fc1cnn(c1)[C@H]1COC2(C1)CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F

InChI Key InChIKey=JXMBJOYAVFVSOX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 474414   

TargetMonoglyceride lipase(Human)
Pfizer

US Patent
LigandPNGBDBM474414(US10858373, Example 12 | 1,1,1,3,3,3-Hexafluoropro...)
Affinity DataIC50: 57nMAssay Description:Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Pfizer

US Patent
LigandPNGBDBM474414(US10858373, Example 12 | 1,1,1,3,3,3-Hexafluoropro...)
Affinity DataIC50: 4.90nMAssay Description:T = 30 minutes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent