BDBM474409 N-[(3R)-8-{[(2,5-Dioxopyrrolidin-1-yl)oxy]carbonyl}-1-oxa-8-azaspiro[4.5]dec-3-yl]-N-methylbenzenesulfonamide ::US10858373, Example 7

SMILES CN([C@H]1COC2(C1)CCN(CC2)C(=O)ON1C(=O)CCC1=O)S(=O)(=O)c1ccccc1

InChI Key InChIKey=UKIABUUNCSUJGX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 474409   

TargetMonoglyceride lipase(Human)
Pfizer

US Patent
LigandPNGBDBM474409(US10858373, Example 7 | N-[(3R)-8-{[(2,5-Dioxopyrr...)
Affinity DataIC50: 214nMAssay Description:Assessment of MAGL inhibition utilizes human recombinant Monoacylglycerol Lipase and the fluorogenic substrate 7-hydroxycoumarinyl arachidonate (7-HC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Pfizer

US Patent
LigandPNGBDBM474409(US10858373, Example 7 | N-[(3R)-8-{[(2,5-Dioxopyrr...)
Affinity DataIC50: 15.6nMAssay Description:T = 30 minutes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2021
Entry Details
Go to US Patent